Formulation: A solid
Formal Name: 5,7-diethyl-3,4-dihydro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one, monohydrochloride
Purity: ≥98%
Formula Markup: C26H26N6O • HCl
Formula Weight: 475
Shelf life (days): 1460
CAS Number: 146709-78-6
Notes: ZD 7155 is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 3.3 nM).{66033} It inhibits angiotensin II-induced pressor responses in conscious normotensive rats in a dose-dependent manner and decreases mean arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 1.082 µmol/kg.{66034} ZD 7155 (10 mg/kg in the drinking water) improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy.{66035} It decreases disease severity and NF-κB and activator protein 1 (AP-1) activation in a mouse model of LPS-induced acute lung injury when administered at a dose of 10 mg/kg.{66036}
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