Formulation: A solid
Formal Name: (3β,22α,25R)-spirosol-5-en-3-yl 4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C39H63NO11
Formula Weight: 721,9
Shelf life (days): 1460
CAS Number: 32449-98-2
Notes: Khasianine is a steroidal glycoside that has been found in S. nigrum and has diverse biological activities.{72017,72018,72019} It reduces the proliferation of LNCaP prostate and T47D breast cancer cells (IC50s = 32.1 and 27.5 µM, respectively). Khasianine (50 nM) inhibits TNF-α-induced nuclear translocation of NF-κB in HaCaT keratinocytes.{72018} It decreases the serum levels of amino transaminase (AST) in a mouse model of carbon tetrachloride-induced liver injury when administered at a dose of 0.1 mg/kg.{72019} Topical administration of khasianine (5 mg/kg) reduces ear epidermal thickness and scaling, as well as leukocyte and macrophage infiltration, in a mouse model of psoriasis induced by the TLR7 agonist imiquimod (Item No. 14956).{72018}
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