Recombinant Human CLEC10A/CD301 Protein (His Tag)

Protein Construction: Recombinant Human C-Type Lectin Domain Family 10 Member A is produced by our Mammalian expression system and the target gene encoding Gln61-His316 is expressed with a 6His tag at the C-terminus.

Sequence: Gln61-His316.

Fusion tag: C-6His.

Accession: Q8IUN9.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Mol Mass: 29.8 kDa.

AP Mol Mass: 40 kDa.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Background: C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

• SKU: ELSPKSH032256-50
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PKSH032256-50
• Green Labware: No
• Package Unit: 50 µg
• Quantity Unit: STK
• Reactivity: Human
• Host: Human