Protein Construction: Recombinant Human Dectin-1 is produced by our Mammalian expression system and the target gene encoding Thr66-Met247 is expressed with a Fc tag at the N-terminus.
Sequence: Thr66-Met247.
Fusion tag: N-Fc.
Accession: Q9BXN2.
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Mol Mass: 46.9 kDa.
AP Mol Mass: 50-65 kDa.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Background: Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.
English
Deutsch
