Recombinant Human Galectin-3/LGALS3 Protein, Low Endotoxin(Active)

Active protein: YES.

Activity: Measured by its ability to agglutinate human red blood cells.The ED50 for this effect is <8 μg/mL.

Protein Construction: A DNA sequence encoding the human Galectin3 (P17931) (Met 1-Ile 250) was expressed and purified.

Sequence: Met 1-Ile 250.

Fusion tag: .

Accession: P17931.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin: < 5 EU per 1 mg of the protein as determined by the LAL method.

Mol Mass: 26.1 kDa.

AP Mol Mass: 30 kDa.

Formulation: Lyophilized from sterile PBS, pH 7.4.

Background: Leukotriene A-4 hydrolase; also known as LTA-4 hydrolase; Leukotriene A (4) hydrolase; LTA4H and LTA4; is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs; arachidonic acid was converted into the unstable intermediate epoxide LTA4; which may in turn be conjugated with glutathione to form the spasmogenic LTC4; or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium; and also modulates immune responses. As a bifunctional zinc metalloenzyme; LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

• SKU: ELSPKSH031707-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PKSH031707-20
• Green Labware: No
• Package Unit: 20 µg
• Quantity Unit: STK
• Reactivity: Human
• Application: Cell Culture
• Host: Escherichia Coli