Recombinant Human KLRB1/CD161 Protein (Fc Tag)

Protein Construction: Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Gln67-Ser225 is expressed with a Fc tag at the C-terminus.

Sequence: Gln67-Ser225.

Fusion tag: C-Fc.

Accession: Q12918.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Mol Mass: 45.6 kDa.

AP Mol Mass: 130 kDa.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Background: Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

• SKU: ELSPKSH032676-10
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PKSH032676-10
• Green Labware: No
• Package Unit: 10 µg
• Quantity Unit: STK
• Reactivity: Human
• Host: Human