Recombinant Human LMAN2/VIP36 Protein (E.coli, His Tag)

Protein Construction: A DNA sequence encoding the human LMAN2 extracellular domain (Q12907) (As p45-Arg 322) was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus.

Sequence: As p45-Arg 322.

Fusion tag: C-His.

Accession: Q12907.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Mol Mass: 33.2 kDa.

AP Mol Mass: 30 kDa.

Formulation: Lyophilized from sterile 50mM Tris, pH 8.5.

Background: The L-type lectin LMAN2 (also known as VIP36) appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway. This may occur due to interference with the adaptor protein GGA1-mediated trans Golgi network-to-endosome transport of GPRC5B.A Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux; respectively.

• SKU: ELSPKSH030834-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PKSH030834-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human
• Host: Escherichia Coli