Protein Construction: Recombinant Human Vesicular Integral-Membrane Protein VIP36 is produced by our Mammalian expression system and the target gene encoding Asp45-Arg322 is expressed with a 6His tag at the C-terminus.
Sequence: Asp45-Arg322.
Fusion tag: C-6His.
Accession: Q12907.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Mol Mass: 32.7 kDa.
AP Mol Mass: 33 kDa.
Formulation: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl,10mM GSH,pH8.0.
Background: Vesicular integral-membrane protein VIP36 is also known as Glycoprotein GP36b; Lectin mannose-binding 2; Vesicular integral-membrane protein 36; LMAN2 and C5orf8. LMAN2 is widely expressed and contains one L-type lectin-like domain. LMAN2 binds high mannose type glycoproteins and may facilitate their sorting; trafficking and quality control. LMAN2 plays a role as an intracellular lectin in the early secretory pathway. LMAN2 interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. LMAN2 is also involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.