Formulation: A solid
Formal Name: N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine, monosodium salt
Purity: ≥95%
Formula Markup: C29H23Cl2N2O7S • Na
Formula Weight: 637,5
Shelf life (days): 1460
CAS Number: 1119276-80-0
Notes: Lifitegrast is an inhibitor of the protein-protein interaction between lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1).{39088} It binds to LFA-1 and blocks the adhesion of Jurkat T cells or HuT 78 cells to ICAM-1 (IC50s = 2.98 and 9 nM, respectively) and inhibits the secretion of various cytokines, including IFN-γ, TNF-α, IL-1β, and IL-6, from these cells.{39085,39088} Lifitegrast increases tear production in dogs with idiopathic keratoconjunctivitis sicca.{39085} Topical application of lifitegrast inhibits LFA-1-dependent neutrophil recruitment to the eye in mouse models of contact lens-associated corneal inflammation induced by corneal abrasion and tobramycin-killed bacteria.{39087} Formulations containing lifitegrast have been used in the treatment of dry eye disease.
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