Formulation: A crystalline solid
Formal Name: N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-acetamide
Purity: ≥98%
Formula Markup: C15H15N5O
Formula Weight: 281,3
Shelf life (days): 1460
CAS Number: 108825-65-6
Notes: Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).{41072} It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).
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