Formulation: A solution in acetonitrile
Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 1-glycerol-1,1,2,3,3-d5 ester
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C23H33D5O4
Formula Weight: 383,6
Shelf life (days): 180
Notes: 1-Arachidonyl-d5-rac-glycerol (1-AG-d5) is intended for use as an internal standard for the quantification of 1-AG (Item No. 62150) by GC- or LC-MS. The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands.{4614} 2-AG is 10 to 100 times more potent than 1-AG in ligand binding affinity and agonist activity at the CB1 receptor,{5306} and is thus considered to be the natural ligand. However, 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency. 1-AG is a weak CB1 receptor agonist and may have other pharmacologic properties.
English
Deutsch
