Formulation: A solid
Formal Name: 2S-amino-3R-hydroxy-4E,8E-octadecadienyl, β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C24H45NO7
Formula Weight: 459,6
Shelf life (days): 1460
CAS Number: 114200-59-8
Notes: 1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Item Nos. 23206 / 23207).{41130} They are formed when sphingosines undergo glucosidation by UDP-glucose.{41131} Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease.{41130,41132} As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1310]
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