Formulation: A solid
Formal Name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl, β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C24H47NO7
Formula Weight: 461,6
Shelf life (days): 1460
CAS Number: 52050-17-6
Notes: 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides (Item Nos. 23206 / 23207 / 25850).{41130} They are formed when sphingosines undergo glucosidation by UDP-glucose.{41131} Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells when used at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a concentration-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (types 2 and 3), thus, glucosylsphingosine has been used as a key biomarker of the disease.{41130,41132} This product contains 1-β-D-glucosylsphingosine (d18:1) isolated from bovine buttermilk. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1306]
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