Formulation: A crystalline solid
Formal Name: 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, monosodium salt
Purity: ≥95%
Formula Markup: C21H44O6P • Na
Formula Weight: 446,5
Shelf life (days): 730
Notes: 1-Oleyl-2-hydroxy-sn-glycero-3-PA (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. LPA binds to one of five different G protein-linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.{13001,2656} Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.{15053}
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