Formulation: A crystalline solid
Formal Name: 9Z-octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, monosodium salt
Purity: ≥95%
Formula Markup: C21H40O7P • Na
Formula Weight: 458,5
Shelf life (days): 1460
CAS Number: 325465-93-8
Notes: 1-Oleoyl-2-hydroxy-sn-glycero-3-PA is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.{2656} Hydrolysis of the fatty acid at the sn-2 position by PLA2 yields bioactive LPA. LPA binds to one of four different G-protein linked receptors{13001} to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.{2656} 1-Oleoyl-2-hydroxy-sn-glycero-3-PA is the most potent of the LPA analogs for calcium mobilization in A431 cells{2665} and for growth stimulation of a variety of cell lines.{2666}
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