Formulation: A solution in ethanol
Formal Name: 10-nitro-9E-octadecenoic acid
Purity: ≥98%
Formula Markup: C18H33NO4
Formula Weight: 327,5
Shelf life (days): 730
CAS Number: 875685-46-4
Notes: Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2; Item No. 10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide.{11912,13284,13287,13288} 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (Item No. 10008042) (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo.{14255} Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.{14255}
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