Formulation: A solid
Formal Name: 11β-hydroxy-pregn-4-ene-3,20-dione
Purity: ≥98%
Formula Markup: C21H30O3
Formula Weight: 330,5
Shelf life (days): 1460
CAS Number: 600-57-7
Notes: 11β-Hydroxyprogesterone (11β-OHP) is a metabolite of progesterone (Item No. 15876).{66048} It is an agonist of the mineralocorticoid receptor (MR) that induces MR transactivation in a reporter assay (EC50 = 0.05 µM for COS-7 cells expressing the human receptor).{66049} It increases sodium absorption in mpkCCDc14 murine renal cortical collecting duct cells. 11β-OHP is an inhibitor of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) and 11β-HSD1 (IC50s = 0.140 and 1 µM, respectively).{66050} It increases blood pressure in rats when administered subcutaneously at a rate of 10 µg/hour.{66051} Serum levels of 11β-OHP are increased in patients with 21-hydroxylase deficiency, a type of congenital adrenal hyperplasia (CAH), characterized by masculinized genitals in female infants, irregular menses in adult females, and accelerated bone age in adolescent males.{66052}
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