Formulation: A solution in ethanol
Formal Name: 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-5Z,8Z-decadienoic acid
Purity: ≥95%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 365
CAS Number: 123931-40-8
Notes: 11S(12R)-EET is an oxylipin and a metabolite of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{39722,52397} It is selectively formed from arachidonic acid by the cytochrome P450 (CYP) isoform CYP2B2 over CYP2C23 and CYP2C24, as well as CYP2C9 over CYP2C8. 11S(12R)-EET (50 nM) activates large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells.{52399} It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 20 pM) and denuded porcine subepicardial arterioles (EC50 = 10 pM). Unlike 11R(12S)-EET (Item No. 9004344), 11S(12R)-EET does not inhibit the epithelial sodium channel (ENaC) in a patch-clamp assay using isolated rat cortical collecting duct tubules or induce migration of human umbilical vein endothelial cells (HUVECs).{72332,72333}
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