Formulation: A solution in ethanol
Formal Name: 5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
Purity: ≥97%
Formula Markup: C20H32O4
Formula Weight: 336,5
Shelf life (days): 365
CAS Number: 83709-73-3
Notes: Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase.{2784} Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM),{11164} and on guinea pig lung membranes with a (Ki of 4.7 mM).{11162} 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.{9270}
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