(±)12-HETE, CAS 71030-37-0

Formulation: A solution in ethanol

Formal Name: (±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid

Purity: ≥95%

Formula Markup: C20H32O3

Formula Weight: 320,5

Shelf life (days): 730

CAS Number: 71030-37-0

Notes: (±)12-HETE is a racemic mixture of the arachidonic acid metabolites 12(R)-HETE (Item No. 34560) and 12(S)-HETE (Item No. 34570). It is formed via non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{54364,54411} 12(S)- and 12(R)-HETE are formed by 12S- and 12R-lipoxygenase-mediated oxidation of arachidonic acid, respectively.{59716,54718,584} 12(R)-HETE can also be formed by oxidation of arachidonic acid mediated by cytochrome P450 (CYP450) enzymes.{54364} (±)12-HETE (1 µM) induces aggregation of isolated human neutrophils.{2091} Production of (±)12-HETE by platelets isolated from spontaneously hypertensive rats is increased compared with platelets isolated from normotensive rats.{3138}

• SKU: CAY34550-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34550-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK