Formulation: A solution in methyl acetate
Formal Name: 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic-3,3,4,4-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C20H24D4O3
Formula Weight: 320,5
Shelf life (days): 730
CAS Number: 1542166-82-4
Notes: 15-deoxy-Δ12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.{1424,1428} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1424}
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