15(R)-Prostaglandin I2 (sodium salt)

Formulation: A crystalline solid

Formal Name: (5Z,9α,11α,13E,15R)-6,9-epoxy-11,15-dihydroxy-prosta-5,13-dien-1-oic acid, monosodium salt

Purity: ≥98%

Formula Markup: C20H31O5 • Na

Formula Weight: 374,4

Shelf life (days): 1460

Notes: 15(R)-Prostaglandin I2 (15(R)-PGI2) is an isomer of the natural 15(S) prostanoid, PGI2 (Item No. 18220). PGI2 is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.{502,443,933} It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM.{4375} While the physiological properties of 15(R)-PGI2 are not well known, 15(R) isomers of PGs typically have reduced receptor agonist activity compared to their 15(S) forms.

• SKU: CAY21586-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21586-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK