Formulation: A solution in ethanol
Formal Name: 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
Purity: ≥98%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 365
CAS Number: 54845-95-3
Notes: 15(S)-HETE is an active metabolite of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{118} It is formed via oxidation of arachidonic acid by 15-lipoxygenase 2 (15-LO-2) in macrophages, as well as the prostate, lung, and skin, but also by 15-LO-1 in airway epithelial cells, eosinophils, and reticulocytes.{55555,54364} 15(S)-HETE inhibits the proliferation of HT-29 colorectal and PC3 prostate cancer cells (IC50s = 40 and 30 µM, respectively).{65512,10005} It increases kruppel-like factor 10 (KLF10) and decreases B cell lymphoma 2 (Bcl-2) protein levels in HT-29 cells when used at a concentration of 40 µM.{65512} 15(S)-HETE (0.1 µM) increases HMG-CoA reductase protein levels in human dermal microvascular endothelial cells (HDMVECs).{55558} It increases Rac1 protein levels and induces farnesylation of Rac1 in HDMVECs when used at a concentration of 0.1 µM.
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