Formulation: A solution in ethanol
Formal Name: (±)16-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Purity: ≥98%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 730
CAS Number: 128914-46-5
Notes: Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure.{3825} At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.{3825}
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