17α-Estradiol, CAS 57-91-0

Formulation: A crystalline solid

Formal Name: (17α)-estra-1,3,5(10)-triene-3,17-diol

Purity: ≥98%

Formula Markup: C18H24O2

Formula Weight: 272,4

Shelf life (days): 1460

CAS Number: 57-91-0

Notes: 17α-Estradiol is the natural optical isomer of 17β-estradiol (Item No. 10006315), the major estrogen secreted by the premenopausal ovary. 17α-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17β-estradiol.{24968} It can inhibit 5α-reductase, which plays a role in regulating hair growth. 17α -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.{24968,13837}

• SKU: CAY20776-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20776-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK