Formulation: A solution in methyl acetate
Formal Name: (3Z)-5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]cyclopentyl]-3-pentenoic acid
Purity: ≥95%
Formula Markup: C18H30O5
Formula Weight: 326,4
Shelf life (days): 730
CAS Number: 221664-05-7
Notes: 8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.{320} 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.{6907} In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.{6907,3026} Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.{6907} 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.{6907} Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.{6907}
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