Formulation: A solid
Formal Name: 2,3-dihydroxy-estra-1,3,5(10)-trien-17-one
Purity: ≥95%
Formula Markup: C18H22O3
Formula Weight: 286,4
Shelf life (days): 1460
CAS Number: 362-06-1
Notes: 2-hydroxy Estrone is an active metabolite of the endogenous estrogen estrone (Item No. 10006485).{57564} It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1A2, CYP1A1, and CYP1B1 and metabolized to 2-methoxy estrone (Item No. 34155) by catechol-O-methyltransferase (COMT). 2-hydroxy Estrone (10 µM) inhibits the proliferation of estrogen receptor-positive MCF-7, but not estrogen receptor-negative MDA-MB-231, breast cancer cells cultured with the COMT inhibitor quinalizarin.{60532} It inhibits iron-ADP-adriamycin complex-induced lipid peroxidation of liposomes prepared from rat liver microsomes (IC50 = 2.7 µM).{60533}
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