2-Methoxyestradiol, CAS 362-07-2

Formulation: A crystalline solid

Formal Name: 2-methoxy-estra-1,3,5(10)-triene-3,17β-diol

Purity: ≥95%

Formula Markup: C19H26O3

Formula Weight: 302,4

Shelf life (days): 1460

CAS Number: 362-07-2

Notes: 2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t½ values of 7.9 and 24.9 minutes, respectively.{16610} 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1α pathway.{16608,16609,16611} The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.{16513}

• SKU: CAY13021-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13021-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK