20-hydroxy Leukotriene B4, CAS 79516-82-8

Formulation: A solution in ethanol

Formal Name: 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid

Purity: ≥97%

Formula Markup: C20H32O5

Formula Weight: 352,5

Shelf life (days): 365

CAS Number: 79516-82-8

Notes: 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL,{399} but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM).{1106} However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung.{377} 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor,{8743,9270} but does not appear to function as an agonist.{8525}

• SKU: CAY20190-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20190-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK