Formulation: A solution in ethanol
Formal Name: 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
Purity: ≥97%
Formula Markup: C20H32O5
Formula Weight: 352,5
Shelf life (days): 365
CAS Number: 79516-82-8
Notes: 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL,{399} but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM).{1106} However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung.{377} 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor,{8743,9270} but does not appear to function as an agonist.{8525}