20(S)-hydroxy Cholesterol, CAS 516-72-3

Formulation: A crystalline solid

Formal Name: cholest-5-ene-3β,20-diol

Purity: ≥98%

Formula Markup: C27H46O2

Formula Weight: 402,7

Shelf life (days): 1460

CAS Number: 516-72-3

Notes: 20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells.{21991} 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo.{21991,40043} 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.{40041,18498,40042}

• SKU: CAY20103-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20103-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK