Formulation: A solid
Formal Name: cholesta-5,24-dien-26,26,26,27,27,27-d6-3β-ol
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C27H38D6O
Formula Weight: 390,7
Shelf life (days): 1460
CAS Number: 1246298-67-8
Notes: 24-dehydro Cholesterol-d6 is intended for use as an internal standard for the quantification of 24-dehydro cholesterol (Item No. 14943) by GC- or LC-MS. 24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies.{26099} During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols.{26098} However, defects in cholesterol synthesis can lead to a condition called desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol.{26100} 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.{26096,26097}
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