Formulation: A crystalline solid
Formal Name: (25R)-cholest-5-ene-3β,26-diol
Purity: ≥95%
Formula Markup: C27H46O2
Formula Weight: 402,7
Shelf life (days): 730
CAS Number: 20380-11-4
Notes: The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}