Formulation: A solid
Formal Name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl, β-D-galactopyranoside, 3-(hydrogen sulfate), monoammonium salt
Purity: ≥98%
Formula Markup: C24H46NO10S • NH4
Formula Weight: 558,7
Shelf life (days): 1460
CAS Number: 1246681-32-2
Notes: 3’-sulfo Galactosylsphingosine is a form of sulfatide (Item No. 24323) that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 µM.{43066} It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 µM, respectively.{43067} 3’-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits.{43068} In mice lacking ASA, levels of 3’-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits.{43067,43068} 3’-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3’-sulfo galactosylsphingosine by LC-MS.{38965} [Matreya, LLC. Catalog No. 1904]
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