4-hydroxy Nonenal Mercapturic Acid, CAS 146764-24-1

4-hydroxy Nonenal Mercapturic Acid, CAS 146764-24-1
SKU
CAY32110-1
Packaging Unit
1 mg
Manufacturer
Cayman Chemical

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Formulation: A solution in ethanol

Formal Name: N-acetyl-S-(tetrahydro-5-hydroxy-2-pentyl-3-furanyl)-L-cysteine

Purity: ≥98%

Formula Markup: C14H25NO5S

Formula Weight: 319,4

Shelf life (days): 365

CAS Number: 146764-24-1

Notes: Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat.{7334} About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates.{8626} The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.
More Information
SKU CAY32110-1
Manufacturer Cayman Chemical
Manufacturer SKU 32110-1
Green Labware No
Package Unit 1 mg
Quantity Unit STK
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