Formulation: A solid
Formal Name: cholest-5-ene-25,26,26,26,27,27,27-d7-3β,4β-diol
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C27H39D7O2
Formula Weight: 409,7
Shelf life (days): 1460
CAS Number: 1246302-80-6
Notes: 4β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4β-hydroxy cholesterol (Item No. 19518) by GC- or LC-MS. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
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