Formulation: A solution in ethanol
Formal Name: (±)-5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid 1,5-lactone
Purity: ≥90%
Formula Markup: C20H30O3
Formula Weight: 318,5
Shelf life (days): 365
Notes: Eicosapentaenoic acid (EPA; Item No. 90110) is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE (Item No. 10467) is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. (±)5(6)-DiHETE lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHETE. While its biological activity is unknown, the selective capacity of (±)5(6)-DiHETE to form this lactone can be utilized to specifically quantify (±)5(6)-DiHETE in biological samples.{29654}