5(S),12(S)-DiHETE, CAS 79056-01-2

Formulation: A solution in ethanol

Formal Name: 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid

Purity: ≥98%

Formula Markup: C20H32O4

Formula Weight: 336,5

Shelf life (days): 365

CAS Number: 79056-01-2

Notes: 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid (AA; Item No. 10006607). It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA.{530} 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes.{577} It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore.{7243} 5(S),12(S)-DiHETE is an epimer of leukotriene B4 (Item No. 20110) that is weakly chemotactic for PMNL.{551}

• SKU: CAY35260-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35260-25
• Green Labware: No
• Package Unit: 25 µg
• Quantity Unit: STK