Formulation: A solution in ethanol
Formal Name: 5S-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid
Purity: ≥98%
Formula Markup: C20H30O3
Formula Weight: 318,5
Shelf life (days): 365
CAS Number: 92008-51-0
Notes: 5(S)-HEPE is an active metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 / 90110.1 / 21908).{1122} It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119).{51501} It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 µM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 µM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.{51502}
English
Deutsch
