Formulation: A crystalline solid
Formal Name: (3β,5α,6α)-5,6-epoxy-cholestan-3-ol
Purity: ≥95%
Formula Markup: C27H46O2
Formula Weight: 402,7
Shelf life (days): 1460
CAS Number: 1250-95-9
Notes: 5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}