Formulation: A crystalline solid
Formal Name: 6-amino-hexanoic acid
Purity: ≥95%
Formula Markup: C6H13NO2
Formula Weight: 131,2
Shelf life (days): 1460
CAS Number: 60-32-2
Notes: 6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).{37233} It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.{37234} Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.{37235}