Formulation: A crystalline solid
Formal Name: (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid
Purity: ≥95%
Formula Markup: C26H44O4
Formula Weight: 420,6
Shelf life (days): 1460
CAS Number: 459789-99-2
Notes: Farnesoid X receptor (FXR) is a nuclear receptor that is activated by bile acid, with chenodeoxycholic acid (CDCA) being a representative natural ligand.{20706} 6-ECDCA is a synthetic bile acid that acts as a potent and selective agonist of FXR (EC50 = 99 nM).{20705} Through FXR, it alters gene expression that results in protection against cholestasis as well as liver fibrosis in animal models.{20705,20702,20703} 6-ECDCA also, through FXR, promotes the differentiation of adipocytes and enhances insulin signaling in mature adipocytes.{20707} In ApoE-/- mice, 6-ECDCA ameliorates vascular calcification secondary to chronic kidney disease without affecting the development of atherosclerosis.{20704}
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