Notes: 7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.{60720} In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.{60721} It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.{60722}