Formulation: A crystalline solid
Formal Name: (3β,7β,25R)-cholest-5-ene-3,7,26-triol
Purity: ≥95%
Formula Markup: C27H46O3
Formula Weight: 418,7
Shelf life (days): 730
CAS Number: 240129-43-5
Notes: 7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt.{33003} It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 / 11932).
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