Formulation: A solution in ethanol
Formal Name: (±)8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid
Purity: ≥98%
Formula Markup: C20H34O4
Formula Weight: 338,5
Shelf life (days): 730
CAS Number: 192461-96-4
Notes: (±)8(9)-DiHET is an oxylipin and a racemic mixture of the arachidonic acid metabolites 8(S),9(R)-DiHET and 8(R),9(S)-DiHET.{729} It is formed from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) via an (±)8(9)-EET (Item No. 50351) intermediate by epoxide hydrolases. (±)8(9)-DiHET (1 µM) induces cAMP production in primary human coronary artery smooth muscle cells.{65635} Plasma levels of (±)8(9)-DiHET are increased in a mouse model of osteoarthritic pain induced by destabilization of the medial meniscus, an effect that can be reversed by the soluble epoxide hydrolase (sEH) inhibitor TPPU (Item No. 11120).{65636} Spinal cord levels of (±)8(9)-DiHET are also increased in a rat model of surgically-induced acute spinal cord injury (SCI).{65637}
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