Formulation: A solution in ethanol
Formal Name: (±)8,9-epoxy-5Z,11Z,14Z,17Z-eicosatetraenoic acid
Purity: ≥95%
Formula Markup: C20H30O3
Formula Weight: 318,5
Shelf life (days): 365
CAS Number: 851378-93-3
Notes: Eicosapentaenoic acid (EPA; Item No. 90110) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms.{18671} The major product of this epoxygenase pathway, (±)17(18)-EpETE (Item No. 50861), relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits.{9825,18669,18670} (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.{18672} The biological actions and physiological effects of this epoxide remain to be determined.