Formulation: A solution in methanol
Formal Name: 9E,11E,13E-octadecatrienoic acid
Purity: ≥97%
Formula Markup: C18H30O2
Formula Weight: 278,4
Shelf life (days): 365
CAS Number: 544-73-0
Notes: 9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid.{37085} It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces apoptosis in T24 bladder cancer cells via production of reactive oxygen species.{37086} It also inhibits bacterial fatty acid dioxygenase with a Ki value of 49 nM in vitro.{37087}
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