Formulation: A solution in ethanol
Formal Name: (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-5-heptenoic acid, 1-methylethyl ester
Purity: ≥98%
Formula Markup: C26H33F3O6
Formula Weight: 498,5
Shelf life (days): 730
CAS Number: 1219032-18-4
Notes: 9-keto Fluprostenol isopropyl ester is an ester derivative of the FP receptor agonist fluprostenol (Item No. 16768) that is oxidized at carbon 9. It is a potential prodrug to 9-keto fluprostenol (Item No. 16781), which could act as an agonist at EP receptors. It is also a potential metabolite of fluprostenol isopropyl ester (travoprost; Item No. 16769) based on the published metabolism of latanoprost (Item No. 16812) by 15-hydroxyprostaglandin dehydrogenase in the monkey cornea.{9831} Certain F-series prostaglandins, such as 6-keto prostaglandin F1α (PGF1α; Item No. 15210), are converted to the corresponding E-series compounds in isolated human platelets.{11048}
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