all-trans Retinoic Acid, CAS 302-79-4

all-trans Retinoic Acid, CAS 302-79-4
SKU
CAY11017-500
Packaging Unit
500 mg
Manufacturer
Cayman Chemical

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Formulation: A crystalline solid

Formal Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

Purity: ≥98%

Formula Markup: C20H28O2

Formula Weight: 300,4

Shelf life (days): 1460

CAS Number: 302-79-4

Notes: all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}
More Information
SKU CAY11017-500
Manufacturer Cayman Chemical
Manufacturer SKU 11017-500
Green Labware No
Package Unit 500 mg
Quantity Unit STK
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