Formulation: A crystalline solid
Formal Name: 2-hydroxy-6-(8Z)-8-pentadecenyl-benzoic acid
Purity: ≥95%
Formula Markup: C22H34O3
Formula Weight: 346,5
Shelf life (days): 730
CAS Number: 22910-60-7
Notes: Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia.{29843,29842} However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts.{29843} Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position.{29843} It inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination.{29841,29844} Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate.{29841} Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.{29845}
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